Reaction: P2RY12 binds ADP
- in pathway: P2Y receptors
P2RY12 (Bodor et al. 2003) is found on the surface of blood platelet cells and is an important regulator in blood clotting. It is one of two ADP receptors expressed in platelets, the other is P2RY1. Activation leads to irreversible platelet aggregation. Defects in this receptor are associated with bleeding disorders. Its preferred ligand is ADP. The platelet anticoagulant drug clopidogrel binds to this receptor (Hollopeter G et al. 2001).
Reaction - small molecule participants:
ADP [extracellular region]
ADP [extracellular region]
Reactome.org reaction link: R-HSA-417829
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Reaction input - small molecules:
ADP(3-)
ADP(3-)
Reaction output - small molecules:
Reactome.org link: R-HSA-417829