Reaction: P2Y5 receptor can bind to LPA
- in pathway: P2Y receptors
The P2Y5 receptor (Lee CW et al, 2006) binds lysophosphatidic acid (LPA). Its effects are mediated by coupling with the G protein alpha G q/11 and G12/13 subunits (Lee CW et al, 2006). Mutations in the P2RY5 gene cause a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth (Pasternack SM et al, 2008).
Reaction - small molecule participants:
LPA [extracellular region]
Reactome.org reaction link: R-HSA-417890
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Reaction input - small molecules:
1-octadec-9-enoylglycero-3-phosphate
Reaction output - small molecules:
Reactome.org link: R-HSA-417890