Reaction: cGMP is degraded by PDEs
- in pathway: cGMP effects
Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.
PDE2, 3 and 5 are expressed in platelets.
Reaction - small molecule participants:
GMP [cytosol]
cGMP [cytosol]
Reactome.org reaction link: R-HSA-418456
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Reaction input - small molecules:
3',5'-cyclic GMP
Reaction output - small molecules:
guanosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-418456