Reaction: cAMP degradation by Phosphodiesterases
- in pathway: G alpha (s) signalling events
Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
cAMP [cytosol]
Reactome.org reaction link: R-HSA-418553
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Reaction input - small molecules:
water
3',5'-cyclic AMP(1-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-418553