Reaction: Phosphorylation of Unc5C
- in pathway: Netrin mediated repulsion signals
Multiple sites on UNC5C are phosphorylated after NTN1 (netrin-1) stimulation. An activated SRC tyrosine kinase induces phosphorylation of UNC5C at multiple cytoplasmic tyrosine residues including highly-conserved residues 449, 454, 568, 649 and 667. Phosphorylation of these residues creates potential binding sites for cytoplasmic signaling proteins.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-418859
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-418859