Reaction: Melatonin receptors can bind melatonin
- in pathway: Class A/1 (Rhodopsin-like receptors)
Melatonin (N-acetyl-5-methoxytryptamine) is a natural hormone produced by the pineal gland that is involved in the regulation of circadian rhythms. These actions are mediated by melatonin receptors. Melatonin can also function as a powerful antioxidant in the protection of nuclear and mitochondrial DNA.There are two melatonin receptors in humans, MT1 (Mel1a, MTNR1A) and MT2 (Mel1b, MTNR1B). Their actions are mediated by coupling with the G protein alpha i/o subunits to inhibit adenylyl cyclase (Reppert SM et al, 1994: Reppert SM et al, 1995).
Reaction - small molecule participants:
MLT [extracellular region]
Reactome.org reaction link: R-HSA-419334
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Reaction input - small molecules:
melatonin
Reaction output - small molecules:
Reactome.org link: R-HSA-419334