Reaction: LPA-binding receptors bind LPA
- in pathway: Lysosphingolipid and LPA receptors
The LPA-binding EDG receptors all bind to the ligand lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent signaling molecule.
EDG2 is a human gene encoding a GPCR, LPA1 (as this receptor binds LPA) (An S et al, 1997). Downstream effects such as inhibition of adenylyl cyclase are mediated by binding to Gi proteins (An S et al, 1998).
EDG4 is a human gene which encodes the GPCR known as LPA2 (An S et al, 1998). This protein contributes towards Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins (An S et al, 1998).
EDG7 encodes the GPCR LPA3. This receptor binds LPA and mediates LPA-evoked calcium mobilization. This receptor couples predominantly to Gq/11 alpha proteins (Im DS et al, 2000).
EDG2 is a human gene encoding a GPCR, LPA1 (as this receptor binds LPA) (An S et al, 1997). Downstream effects such as inhibition of adenylyl cyclase are mediated by binding to Gi proteins (An S et al, 1998).
EDG4 is a human gene which encodes the GPCR known as LPA2 (An S et al, 1998). This protein contributes towards Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins (An S et al, 1998).
EDG7 encodes the GPCR LPA3. This receptor binds LPA and mediates LPA-evoked calcium mobilization. This receptor couples predominantly to Gq/11 alpha proteins (Im DS et al, 2000).
Reaction - small molecule participants:
LPA [extracellular region]
Reactome.org reaction link: R-HSA-419389
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Reaction input - small molecules:
1-octadec-9-enoylglycero-3-phosphate
Reaction output - small molecules:
Reactome.org link: R-HSA-419389