Reaction: CASR binds Ca2+
- in pathway: Class C/3 (Metabotropic glutamate/pheromone receptors)
The parathyroid glands play a role in ion homeostasis by sensing small changes in extracellular Ca2+ ion concentration. These glands express a cell surface receptor, calcium-sensing receptors (CaR) (Garrett JE et al, 1995) that is activated by increases in the concentration of extracellular calcium and by a variety of other cations. CaR serves as the primary physiological regulator of parathyroid hormone (PTH) secretion. CaR contributes to regulation of systemic calcium homeostasis by activation of Gq- (Kifor O et al, 1997) and Gi-linked (Kifor O et al, 2001) signaling pathways in the parathyroid glands, kidney and intestine.
Reaction - small molecule participants:
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-420724
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-420724