Reaction: trans-Golgi Network Derived Vesicle Uncoating
- in pathway: Golgi Associated Vesicle Biogenesis
The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the Golgi-associated vesicle membrane.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-421836
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-421836