Reaction: Na+-driven Cl-/HCO3- exchanger transport
- in pathway: Bicarbonate transporters
Two genes encode Na+-dependent Cl-/HCO3- exchangers; SLC4A8 (NDCBE1) and 10 (NCBE). SLC4A8 (NDCBE1) encodes a exchanger protein which mediates Na+:HCO3- transport with a stoichiometry of 1:2:1 (Na+/HCO3-/Cl-). This protein is highly expressed in brain and spine and moderately expressed in trachea, thyroid, and kidney (Amlal H et al, 1999). SLC4A10 (NCBE, NBCn2) encodes a Na+-driven Cl-/HCO3- exchanger protein (Parker MD et al, 2008). It transports extracellular Na+ and HCO3- into cells in exchange for intracellular Cl- and H+, thus raising the intracellular pH.
Reaction - small molecule participants:
H+ [extracellular region]
Cl- [extracellular region]
HCO3- [cytosol]
Na+ [cytosol]
H+ [cytosol]
HCO3- [extracellular region]
Cl- [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-425577
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Reaction input - small molecules:
hydron
hydrogencarbonate
chloride
sodium(1+)
Reaction output - small molecules:
hydron
chloride
hydrogencarbonate
sodium(1+)
Reactome.org link: R-HSA-425577