Reaction: SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+
- in pathway: Sodium/Calcium exchangers
The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. NCKX1 (SLC24A1) encodes an exchanger protein which is the most extensively studied member (Tucker et al. 1998). It is highly expressed in the eye. Other members are expressed in the brain and skin as well as the eye (Prinsen et al. 2000, Kraev et al. 2001, Li et al. 2002, Lamason et al. 2005).
Reaction - small molecule participants:
K+ [extracellular region]
Na+ [cytosol]
Ca2+ [extracellular region]
K+ [cytosol]
Ca2+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-425678
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Reaction input - small molecules:
potassium(1+)
calcium(2+)
sodium(1+)
Reaction output - small molecules:
potassium(1+)
sodium(1+)
calcium(2+)
Reactome.org link: R-HSA-425678