Reaction: SLC9A6,7 exchange Na+ for H+ across the early endosome membrane
- in pathway: Sodium/Proton exchangers
NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.
Reaction - small molecule participants:
H+ [cytosol]
Na+ [early endosome lumen]
H+ [early endosome lumen]
Na+ [cytosol]
Reactome.org reaction link: R-HSA-425983
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Reaction input - small molecules:
hydron
sodium(1+)
Reaction output - small molecules:
hydron
sodium(1+)
Reactome.org link: R-HSA-425983