Reaction: Na+/H+ exchanger transport (at cell membrane)
- in pathway: Sodium/Proton exchangers
NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.
Reaction - small molecule participants:
H+ [extracellular region]
Na+ [cytosol]
H+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-425994
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Reaction input - small molecules:
hydron
sodium(1+)
Reaction output - small molecules:
hydron
sodium(1+)
Reactome.org link: R-HSA-425994