Reaction: 2-AG hydrolysis to arachidonate by MAGL
- in pathway: Arachidonate production from DAG
Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol to arachidonate and glycerol. In adipocytes MAGL and hormone-sensitive lipase (LIPE) hydrolyze intracellular triglyceride stores. MAGL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
Reaction - small molecule participants:
AA [plasma membrane]
H+ [cytosol]
Glycerol [cytosol]
H2O [cytosol]
2AG [plasma membrane]
Reactome.org reaction link: R-HSA-426043
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Reaction input - small molecules:
water
2-arachidonoylglycerol
Reaction output - small molecules:
arachidonate
hydron
glycerol
Reactome.org link: R-HSA-426043