Reaction: SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol
- in pathway: Cation-coupled Chloride cotransporters
Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.
Reaction - small molecule participants:
K+ [cytosol]
Na+ [cytosol]
Cl- [cytosol]
K+ [extracellular region]
Cl- [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-426086
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Reaction input - small molecules:
potassium(1+)
chloride
sodium(1+)
Reaction output - small molecules:
potassium(1+)
sodium(1+)
chloride
Reactome.org link: R-HSA-426086