Reaction: DAG activation of TRPC channels
- in pathway: Effects of PIP2 hydrolysis
TRPC3, 6 and 7 are non-selective cation channels that are activated by diacylglycerol (DAG) independently of protein kinase C activation by DAG. By analogy with the structures of voltage-regulated calcium channels, TRPC channels are probably tetramers of TRPC protein; heterotetramers within the 3/6/7 group have been observed.
Reaction - small molecule participants:
DAG [plasma membrane]
Reactome.org reaction link: R-HSA-426209
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Reaction input - small molecules:
1,2-diacyl-sn-glycerol
Reaction output - small molecules:
Reactome.org link: R-HSA-426209