Reaction: DAG kinase produces phosphatidic acid from DAG
- in pathway: Effects of PIP2 hydrolysis
Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.
Reaction - small molecule participants:
1,2-daG3P [cytosol]
ADP [cytosol]
ATP [cytosol]
DAG [plasma membrane]
Reactome.org reaction link: R-HSA-426240
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Reaction input - small molecules:
ATP(4-)
1,2-diacyl-sn-glycerol
Reaction output - small molecules:
1,2-diacyl-sn-glycerol 3-phosphate
ADP(3-)
Reactome.org link: R-HSA-426240