Reaction: eNoSC deacetylates histone H3
- in pathway: SIRT1 negatively regulates rRNA expression
The Sirtuin-1 (SIRT1) component of eNoSC deacetylates histone H3 at lysine-9 (Vaquero et al. 2004, Murayama et al. 2008). The reaction uses nicotinamide adenine dinucleotide (NAD) as the acceptor of the acetyl group and generates nicotinamide and 1-O-acetyl-ADP-ribose as products (Vaquero et al. 2004). The use of NAD links the reaction to the overall energy balance of the cell. Cells exposed to high glucose have a greater NADH:NAD ratio and therefore lower activity of eNoSC (Murayama et al. 2008). Low glucose produces higher NAD and higher activity of eNoSC.
Reaction - small molecule participants:
NAM [nucleoplasm]
2'-O-acetyl-ADP-ribose [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-427514
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
2''-O-acetyl-ADP-D-ribose
Reactome.org link: R-HSA-427514