Reaction: Group 3 - Selective Cl- transport
- in pathway: Multifunctional anion exchangers
Group 3 members (SLC26A7 and 9) function as ion channels. SLC26A7 encodes an ion channel which is abundantly expressed in medullary collecting duct cells of the kidney, high endothelial venule enothelial cells (HEVEC) and gastric parietal cells (Vincourt JB et al, 2002; Lohi H et al, 2002). SLC26A9 encodes an ion channel which is predominantly expressed on the lumenal side of the bronchiolar and alveolar epithelium of lung (Lohi H et al, 2002). Both these ion channels appear to transport Cl- without cotransport of HCO3- (Kim KH et al, 2005; Dorwart MR et al, 2007).
Reaction - small molecule participants:
Cl- [cytosol]
Cl- [extracellular region]
Reactome.org reaction link: R-HSA-427570
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Reaction input - small molecules:
chloride
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-427570