Reaction: SLC34A3 cotransports Pi, 2Na+
- in pathway: Type II Na+/Pi cotransporters
SLC34A3 is almost exclusively expressed in the kidney and encodes the Na+/Pi cotransporter NaPi-IIc (Segawa et al. 2002). The protein is located at apical membranes of proximal tubules. It cotransports two Na+ ions with every Pi (electroneutral transport). Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (Bergwitz et al. 2006).
Reaction - small molecule participants:
Pi [cytosol]
Na+ [cytosol]
Pi [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-427645
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Reaction input - small molecules:
hydrogenphosphate
sodium(1+)
Reaction output - small molecules:
hydrogenphosphate
sodium(1+)
Reactome.org link: R-HSA-427645