Reaction: SLC26A3,6 exchange Cl- for HCO3-
- in pathway: Multifunctional anion exchangers
The proteins responsible for the exchange of chloride (Cl-) with bicarbonate (HCO3-) are members of the SLC4 (1-3) and SLC26 (3 and 6) transporter families. SLC4 members are discussed in the section "Bicarbonate transporters".
SLC26A3 (Chloride anion exchanger, Down-regulated in adenoma, DRA) is expressed in the mucosa of the colon and helps mediate electrolyte and fluid absorption (Schweinfest et al. 1993). Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterized by watery stools containing an excess of chloride (Hoeglund et al. 1996). SLC26A6 encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate (Waldegger et al. 2001). It is ubiquitously expressed, the highest levels present in kidney and pancreas.
SLC26A3 (Chloride anion exchanger, Down-regulated in adenoma, DRA) is expressed in the mucosa of the colon and helps mediate electrolyte and fluid absorption (Schweinfest et al. 1993). Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterized by watery stools containing an excess of chloride (Hoeglund et al. 1996). SLC26A6 encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate (Waldegger et al. 2001). It is ubiquitously expressed, the highest levels present in kidney and pancreas.
Reaction - small molecule participants:
HCO3- [extracellular region]
Cl- [cytosol]
Cl- [extracellular region]
HCO3- [cytosol]
Reactome.org reaction link: R-HSA-427666
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Reaction input - small molecules:
chloride
hydrogencarbonate
Reaction output - small molecules:
hydrogencarbonate
chloride
Reactome.org link: R-HSA-427666