Reaction: sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP
- in pathway: Sphingolipid de novo biosynthesis
SPHK1 and 2 (sphingosine kinases 1 and 2) each catalyze the reaction of sphinganine (dihydrosphingosine) and ATP to form dihydrosphingosine 1-phosphate and ADP. Both enzymes are found in the cytosol (although they are also present in membrane-associated forms). Both enzymes also catalyze the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P) (Liu et al. 2000, Nava et al. 2000, Pitson et al. 2000).
Reaction - small molecule participants:
ADP [cytosol]
SPAP [cytosol]
ATP [cytosol]
SPA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-428214
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Reaction input - small molecules:
ATP(4-)
sphinganine
Reaction output - small molecules:
ADP(3-)
sphinganine 1-phosphate
Reactome.org link: R-HSA-428214