Reaction: phytoceramide + H2O => stearate + phytosphingosine
- in pathway: Sphingolipid metabolism
ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of phytoceramide to yield a free fatty acid (annotated here as stearate) and phytosphingosine. ACER3 mRNA is widely expressed in the body, although most abundant in placenta. Immunofluoresence studies of cultured cells over-expressing GFP-tagged protein suggest its localization to membranes of the endoplasmic reticulum (annotated here) and also the Golgi apparatus (Mao et al. 2001).
Reaction - small molecule participants:
phytosphingosine [endoplasmic reticulum membrane]
STEA [cytosol]
H2O [cytosol]
N-acylphytosphingosine [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-428262
======
Reaction input - small molecules:
water
N-acylphytosphingosine
Reaction output - small molecules:
phytosphingosine
magnesium distearate
Reactome.org link: R-HSA-428262