Reaction: SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol
- in pathway: Acetylcholine Neurotransmitter Release Cycle
The human SLC5A7 gene encodes a sodium- and chloride-dependent, high affinity choline transporter, CHT (Apparsundaram et al. 2000). CHT transports choline (Cho) from the extracellular space into neuronal cells and is dependent on Na+ and Cl- ions for transport (Okuda & Haga 2000). Choline uptake is the rate-limiting step in acetylcholine synthesis.
Reaction - small molecule participants:
Cho [cytosol]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Cho [extracellular region]
Na+ [extracellular region]
Cho [cytosol]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Cho [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-429594
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Reaction input - small molecules:
chloride
choline
sodium(1+)
chloride
choline
sodium(1+)
Reaction output - small molecules:
choline
sodium(1+)
chloride
choline
sodium(1+)
chloride
Reactome.org link: R-HSA-429594