Reaction: SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol
- in pathway: Inositol transporters
The human SLC5A3 gene encodes a Na+/myo-inositol (Ins) transporter also known as SMIT1 (Berry et al. 1995). The stoichiometry and inositol specificity of the human transport reaction are inferred from the properties of cloned canine protein expressed in Xenopus oocytes (Hager et al. 1995). SMIT1 functions in cellular osmoregulation and is expressed in many human tissues including skeletal muscle, brain, kidney, and placenta.
Reaction - small molecule participants:
Ins [cytosol]
Na+ [cytosol]
Ins [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-429663
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Reaction input - small molecules:
myo-inositol
sodium(1+)
Reaction output - small molecules:
myo-inositol
sodium(1+)
Reactome.org link: R-HSA-429663