Reaction: CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus
- in pathway: Sphingolipid de novo biosynthesis
CERT1-2 (ceramide transfer protein, isoform 2), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). CERT1-2-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).
Reaction - small molecule participants:
CERA [Golgi membrane]
Reactome.org reaction link: R-HSA-429683
======
Reaction input - small molecules:
Reaction output - small molecules:
N-acylsphingoid
Reactome.org link: R-HSA-429683