Reaction: PRKD1,2,3 phosphorylates CERT1-2
- in pathway: Sphingolipid de novo biosynthesis
Cytosolic PRKD1, 2 and 3 (protein kinase D1, D2 and D3) catalyze the phosphorylation of serine residue 132 of isoform 2 of ceramide transfer protein (CERT1-2, aka COL4A3BP-2). Protein kinase D (PRKD) is as a crucial regulator of secretory transport at the trans-Golgi network (TGN). Phosphorylation of COL4A3BP-2 reduces its ceramide transfer activity. PRKDs may therefore act as regulators of lipid homeostasis (Fugmann et al. 2007).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-429698
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-429698