Reaction: SLC5A8 transports monocarboxylates from extracellular region to cytosol
- in pathway: Nicotinamide salvaging
The human tumour suppressor gene SLC5A8 encodes sodium-coupled monocarboxylate transporter 1, SMCT1 (also called AIT) and is abundantly expressed in the colon (Coady et al. 2004, Myauchi et al. 2004). When the human protein is expressed in Xenopus oocytes, it was found to transport small monocarboxylates and carboxylate drugs, co-transporting Na+ ions electrogenically (3 Na+ ions co-transported with 1 carboxylate).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-429749
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Reaction input - small molecules:
sodium(1+)
sodium(1+)
Reaction output - small molecules:
sodium(1+)
sodium(1+)
Reactome.org link: R-HSA-429749