Reaction: DCP1-DCP2 complex decaps mRNA
- in pathway: mRNA decay by 5' to 3' exoribonuclease
The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.
Reaction - small molecule participants:
7-MeGDP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-429860
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Reaction input - small molecules:
water
Reaction output - small molecules:
7-methylguanosine
Reactome.org link: R-HSA-429860