Reaction: PARN deadenylates mRNA
- in pathway: Deadenylation of mRNA
The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-429992
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Reaction input - small molecules:
water
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-429992