Reaction: PAN2-PAN3 complex partially deadenylates mRNA
- in pathway: Deadenylation of mRNA
The PAN2-PAN3 exoribonuclease complex hydrolyzes the poly(A) tail of a mRNA, shortening the tail from about 200 adenosine residues to about 80 adenosine residues and yielding adenosine 5'-monophosphate. PAN2 is the exoribonuclease component of the complex; PAN3 is required for cellular localization. The poly(A)-binding protein (PABP) interacts with PAN3 and recruits the PAN2-PAN3 complex to mRNA.
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-430021
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Reaction input - small molecules:
water
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-430021