Reaction: Aquaporin-7 passively transports glycerol out of cell
Aquaporin-7 (AQP7) passively transports glycerol and water across the plasma membrane according to the osmotic gradient. AQP7 is expressed in adipocytes under the direct control of the PPARG and RXRA nuclear receptors. Expression of AQP7 correlates with release of glycerol from adipocytes. AQP7 is seen to translocate from the nuclear periphery to the plasma membrane during adrenaline-stimulated lipolysis. In rat AQP7 also transports urea.
Reaction - small molecule participants:
glycerol [extracellular region]
Glycerol [cytosol]
Reactome.org reaction link: R-HSA-432074
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Reaction input - small molecules:
glycerol
Reaction output - small molecules:
glycerol
Reactome.org link: R-HSA-432074