Reaction: Ca2+ influx into the post-synaptic cell
NMDA receptors are activated upon binding of two ligands, glutamate and glycine or D-serine. The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse (Cairns et al. 2003, reviewed by Luscher and Malenka 2012 and Sanz-Clemente et al. 2013).
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-432164
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-432164