Reaction: trans-Golgi Network Derived Lysosomal Vesicle Uncoating
- in pathway: Lysosome Vesicle Biogenesis
The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the lysosome membrane.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-432688
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-432688