Reaction: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly
- in pathway: Lysosome Vesicle Biogenesis
Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the lysosome vesicle. Here only 5 clathrin triskelions are represented, though in reality many more would be involved in sculpting an entire vesicle.
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-432706
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-432706