Reaction: NaDC1 co-transports dicarboxylic acids and a sodium ion
Mammalian sodium/dicarboxylate cotransporters (transport succinate and other Krebs cycle intermediates) fall into two categories based on their substrate affinity. The human gene SLC13A2 encodes a low-affinity sodium/dicarboxlate co-transporter, NaDC1. NaDC1 is highly expressed in the brush-border membranes of kidney and intestinal cells and reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate (Pajor AM, 1996).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-433131
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Reaction input - small molecules:
sodium(1+)
Reaction output - small molecules:
sodium(1+)
Reactome.org link: R-HSA-433131