Reaction: Translocation and activation of PKC alpha in response to WNT signaling
- in pathway: Ca2+ pathway
Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos results in PKC translocation to the plasma membrane in a G-protein-dependent manner (Sheldahl et al, 1999; reviewed in Kuhl et al, 2000). PKC activation in response to WNT5A has also been demonstrated in human metastatic melanoma cell lines, contributing to cytoskeletal reorganization leading to invasiveness and motility as well as promoting the epithelial to mesenchymal transition (Weeraratna et al, 2002; Dissanyake et al, 2007; O'Connell et al, 2009)
Reaction - small molecule participants:
PS [plasma membrane]
DAG [plasma membrane]
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-4332390
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Reaction input - small molecules:
3-sn-phosphatidyl-L-serine
1,2-diacyl-sn-glycerol
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-4332390