Reaction: ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell
ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.
Reaction - small molecule participants:
PPi [cytosol]
PALM-CoA [cytosol]
AMP [cytosol]
ATP [cytosol]
PALM [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-434382
======
Reaction input - small molecules:
ATP(4-)
hexadecanoic acid
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
palmitoyl-CoA(4-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-434382