Reaction: PI(3,4,5)P3 binds VAV1,2,3
- in pathway: VEGFA-VEGFR2 Pathway
Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-434637
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-434637