Reaction: NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
- in pathway: Ion influx/efflux at host-pathogen interface
Natural resistance-associated macrophage proteins (NRAMPs) regulate macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating bivalent metal ion transport across macrophage membranes and the subsequent use of these ions in the Fenton/and or Haber–Weiss reactions of free radical formation.
The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes.
The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes.
Reaction - small molecule participants:
H+ [phagocytic vesicle lumen]
H+ [cytosol]
H+ [phagocytic vesicle lumen]
H+ [cytosol]
H+ [phagocytic vesicle lumen]
H+ [cytosol]
Reactome.org reaction link: R-HSA-435171
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Reaction input - small molecules:
hydron
hydron
hydron
Reaction output - small molecules:
hydron
hydron
hydron
Reactome.org link: R-HSA-435171