Reaction: PECAM1 is phosphorylated
- in pathway: Platelet sensitization by LDL
LDL causes a transient increase in p38 MAPK activity in platelets. After an initial phase in which LDL leads to the activation of p38MAPK, LDL leads to tyrosine phosphorylation and thereby activation of PECAM-1, which in turn leads to binding and stimulation of the Ser/Thr phosphatases PP1/PP2A which reduce the activity of p38MAPK by dephosphorylation.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-435244
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-435244