Reaction: ZnT5 transports zinc into secretory granules in pancreatic beta cells
- in pathway: Zinc efflux and compartmentalization by the SLC30 family
The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.
Reaction - small molecule participants:
Zn2+ [secretory granule lumen]
Zn2+ [cytosol]
Zn2+ [secretory granule lumen]
Zn2+ [cytosol]
Reactome.org reaction link: R-HSA-437085
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Reaction input - small molecules:
zinc(2+)
zinc(2+)
Reaction output - small molecules:
zinc(2+)
zinc(2+)
Reactome.org link: R-HSA-437085