Reaction: Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL
- in pathway: Synthesis of Dolichyl-phosphate
In mammals, polyprenol pyrophosphate (pPPP) requires dephosphorylation to polyprenol (pPNOL), which can then be reduced. Although pPPP phosphatase activity has been reported (Wolf et al. 1991), no pPPP phosphatase enzyme has yet been identified (Schenk et al. 2001).
Reaction - small molecule participants:
PPi [cytosol]
pPNOL [integral component of cytoplasmic side of endoplasmic reticulum membrane]
pPPP [integral component of cytoplasmic side of endoplasmic reticulum membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-4419986
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Reaction input - small molecules:
polyprenyl diphosphate
water
Reaction output - small molecules:
diphosphate(3-)
ditrans,polycis-polyprenol
Reactome.org link: R-HSA-4419986