Reaction: SFKs phosphorylate PLCG1
- in pathway: VEGFR2 mediated cell proliferation
Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-4420121
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-4420121