Reaction: Phosphorylation of SRC-1
- in pathway: VEGFA-VEGFR2 Pathway
SRC is activated in vivo and in vitro in a VEGF/SH2D2A-dependent manner. VEGF induces phosphorylation of the activating Y418 residue, located on the c-SRC kinase activation loop, but also decreases phosphorylation of the negative regulatory Y527 (Sun et al. 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-4420206
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-4420206