Reaction: hZIP5 mediates zinc uptake by cells
- in pathway: Zinc influx into cells by the SLC39 gene family
The human gene SLC39A5 encodes the zinc transporter hZIP5 (Wang F et al, 2004). Highest expressions are seen in liver, kidney, pancreas and throughout the small intestine and colon with little expression detected in other tissues. hZIP5 is localized to the basolateral membrane of cells in these tissues. The functionality of ZIP5 as a zinc transporter was determined using mouse protein (mZIP5) (Wang F et al, 2004).
Reaction - small molecule participants:
Zn2+ [cytosol]
Zn2+ [extracellular region]
Reactome.org reaction link: R-HSA-442405
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Reaction input - small molecules:
zinc(2+)
Reaction output - small molecules:
zinc(2+)
Reactome.org link: R-HSA-442405