Reaction: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
- in pathway: Serotonin clearance from the synaptic cleft
Serotonin (5HT) is a monoamine neurotransmitter. It's clearance (and therefore termination) from the synaptic cleft is mediated by the sodium- and chloride-dependent serotonin transporter SERT (SLC6A4, aka 5HTT). SERT is encoded by the human gene SLC6A4 and is expressed in the CNS, PNS and platelets (Ramamoorthy et al. 1993, Brenner et al. 2007, Canli & Lesch 2007).
Reaction - small molecule participants:
5HT [cytosol]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
5HT [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-444008
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Reaction input - small molecules:
chloride
serotonin(1+)
sodium(1+)
Reaction output - small molecules:
serotonin(1+)
sodium(1+)
chloride
Reactome.org link: R-HSA-444008