Reaction: PROT mediates L-proline uptake
- in pathway: Na+/Cl- dependent neurotransmitter transporters
The amino acid L-proline can act as a neurotransmitter. Its actions are terminated by its re-uptake from the synaptic cleft into the pre-synaptic terminal in the brain. This re-uptake is mediated by a sodium-dependent proline transporter, PROT (Shafqat S et al, 1995).
Reaction - small molecule participants:
Na+ [cytosol]
L-Pro [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
L-Pro [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-444100
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Reaction input - small molecules:
chloride
L-proline zwitterion
sodium(1+)
Reaction output - small molecules:
sodium(1+)
L-proline zwitterion
chloride
Reactome.org link: R-HSA-444100