Reaction: RhCG mediates ammonium influx into kidney collecting duct cells
- in pathway: Rhesus glycoproteins mediate ammonium transport.
The human gene RhCG encodes the Rhesus blood group family type C glycoprotein which is mainly expressed in kidney collecting duct but also found in testis. RhCG is located on the apical membrane and mediates the bi-directional transport of ammonium into and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Liu Z et al, 2000; Marini AM et al, 2000).
Reaction - small molecule participants:
H+ [extracellular region]
NH4+ [cytosol]
H+ [cytosol]
NH4+ [extracellular region]
Reactome.org reaction link: R-HSA-444393
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Reaction input - small molecules:
hydron
ammonium
Reaction output - small molecules:
hydron
ammonium
Reactome.org link: R-HSA-444393