Reaction: RhBG mediates ammonium effflux out of kidney collecting duct cells
- in pathway: Rhesus glycoproteins mediate ammonium transport.
The human gene RhBG encodes a Rhesus blood group family type B glycoprotein which is expressed mainly in the kidney but is also found in the liver. The liver and kidney are important tissues for ammonium metabolism and excretion. RhBG is located on the basolateral membrane and mediates the reversible transport of ammonium in and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Ludewig U, 2004; Liu Z et al, 2001).
Reaction - small molecule participants:
H+ [cytosol]
NH4+ [extracellular region]
H+ [extracellular region]
NH4+ [cytosol]
Reactome.org reaction link: R-HSA-444419
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Reaction input - small molecules:
hydron
ammonium
Reaction output - small molecules:
hydron
ammonium
Reactome.org link: R-HSA-444419